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Seminars/Conference talks by Shuang Liu
Upcoming
National University of Singapore, Department of Biological Sciences, Speaker
"Next-Generation Discovery of Bifunctionals and Molecular Glues using DNA-Encoded Libraries "
NUS, Singapore, October 2025
Past
Nanyang Technological University, School of Biological Sciences seminar, Speaker
"Next-Generation Discovery of Bifunctionals and Molecular Glues using DNA-Encoded Libraries "
NTU, Singapore, 11 August 2025
12th International Symposium on DNA-encoded Chemical Libraries, Speaker
"Molecular Glue discovery using DEL"
Shanghai, China, 13 October 2024
Drug Discovery Chemistry, Speaker and Session Moderator
"Rational Screening for Cooperativity in Small Molecule Inducers of Protein-Protein Associations"
San Diego, USA, 4 April 2024
Dana-Farber Targeted Protein Degradation webinar, Speaker
"Rational Screening for Cooperativity in Small Molecule Inducers of Protein-Protein Associations"
Webinar, 16 November 2023
University of Oxford, Hypoxia seminar, Speaker
"Rational Screening for VHL-based molecular glues"
Webinar, 9 June 2023
Imperial College London, ChemBio seminar, Speaker
"Rational Screening for molecular glues"
Imperial College London (White City campus), UK, 6 January 2023
Publications
1. Y. T. Chow, B. Tong, Z. T. Tan, A. Tutter, Z. Nan, P. Horton, M. Romanowski, F. Zécri, S. L. Schreiber, S. Liu*, Selectivity Profiling of Bromodomain PROTACs using Chemical Inducers of Proximity DNA-Encoded Library Screening, ACS Chem. Biol. 20 (9), 2266–2276 (2025) (*corresponding author)
2. S. Iqbal, W. Jiang, E. Hansen, T. Aristotelous, S. Liu, A. Reidenbach, C. Raffier, A. Leed, C. Chen, L. Chung, E. Sigel, A. Burgin, S. Gould, H. H. Soutter, Evaluation of DNA encoded library and machine learning model combinations for hit discovery. npj Drug Discovery 2, 5 (2025).
3. Z. Y. Tan, J. K. A. Adade, X. Gu, C. J. S. Hecht, M. Salcius, B. Tong, S. Liu, S. Hwang, F. J. Zécri, D. B. Graham, S. L. Schreiber, R. J. Xavier, Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator. Cell Chem. Biol. 32, 498-510.e35 (2025).
4. J. W. Mason, Y. T. Chow, L. Hudson, A. Tutter, G. Michaud, M. V. Westphal, W. Shu, X. Ma, Z. Y. Tan, C. W. Coley, P. A. Clemons, S. Bonazzi, F. Berst, K. Briner, S. Liu*, F. J. Zécri*, S. L. Schreiber*, DNA-encoded library-enabled discovery of proximity-inducing small molecules. Nat. Chem. Biol., 20, 170–179 (2024) (*co-corresponding author)
5. S. Liu*, B. Tong, J. W. Mason, J. O. Ostrem, A. Tutter, B. K. Hua, S. A. Tang, S. Bonazzi, K. Briner, F. Berst, F. J. Zécri, S. L. Schreiber*, Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein Associations. J. Am. Chem. Soc. 145 (42), 23281–23291 (2023) (*co-corresponding author)
6. L. Hudson, J. W. Mason, M. V. Westphal, M. J. R. Richter, J. R. Thielman, B. K. Hua, C. J. Gerry, G. Xia, H. L. Osswald, J. M. Knapp, Z. Y. Tan, P. Kokkonda, B. I. C. Tresco, S. Liu, A. G. Reidenbach, K. S. Lim, J. Poirier, J. Capece, S. Bonazzi, C. M. Gampe, N. J. Smith, J. E. Bradner, C. W. Coley, P. A. Clemons, B. Melillo, J. Ottl, C. E. Dumelin, J. V. Schaefer, A. M. Faust, F. Berst, S. L. Schreiber, F. J. Zécri, K. Briner, Diversity-oriented synthesis encoded by deoxyoligonucleotides. Nat. Commun., 14 (1), 4930 (2023)
7. S. Liu, M. Abboud, V. Mikhailov, X. Liu, R. Reinbold, C. J. Schofield, Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors. J. Med. Chem., 66, 5279–5288 (2023)
8. X. Liu, R. Reinbold, S. Liu†, R. A. Herold†, P. Rabe†, S. Duclos, R. B. Yadav, M. I. Abboud, S. Thieffine, F. A. Armstrong, L. Brewitz and C. J. Schofield, Natural and Synthetic 2-Oxogluturate Derivatives Are Substrates for Oncogenic Variants of Human Isocitrate Dehydrogenase 1 and 2. J. Biol. Chem., 102873 (2023) (†co-third author)
9. J. Anantharajan, N. Baburajendran, G. Lin, Y. Y. Loh, W. Xu, N. H. B. Ahmad, S. Liu, A. E. Jasson, J. W. L. Kuan, E. Y. Ng, Y. K. Yeo, A. W. Hung, J. Joy, J. Hill, H. L. Ford, R. Zhao, T. H. Keller and C. Kang, Structure–activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase. Protein Sci. 31, 422-431 (2022)
10. S. Liu, M. I. Abboud, T. John, V. Mikhailov, I. Hvinden, J. Walsby-Tickle, X. Liu, I. Petinatti, T. Cadoux-Hudson, J. S. O. McCullagh, C. J. Schofield, Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1. Commun. Biol. 4, 1243 (2021)
11. S. Liu, T. Cadoux-Hudson, C. J. Schofield. Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities. Curr. Opin. Chem. Biol. 57, 122–134 (2020)
12. J. P. Quek†, S. Liu†, Z. Zhang, Y. Li, E. Y. Ng, Y. R. Loh, A. W. Hung, D. Luo and C. Kang, Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease. Antiviral Res. 175, 104707 (2020) (†co-first author)
13. Y. Li, S. Liu, E. Y. Ng, R. Li, A. Poulsen, J. Hill, A. V. Pobbati, A. W. Hung, W. Hong, T. H. Keller and C. Kang. Structural and ligand-binding analysis of the YAP-binding domain of transcription factor TEAD4. Biochem. J. 475, 2043–2055 (2018)
14. Y. Li, H. Q. Ng, A. Ngo, S. Liu, Y. W. Tan, P. Z. Kwek, A. W. Hung, J. Joy, J. Hill, T. H. Keller and C. Kang, Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor. Biomol. NMR Assign. 11, 225–229 (2017)
15. Y. Li, Z. Zhang, W. W. Phoo, Y. R. Loh, W. Wang, S. Liu, M. W. Chen, A. W. Hung, T. H. Keller, D. Luo and C. Kang, Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors. Structure 25, 1242-1250.e3 (2017)
16. Y. Li, Y. L. Wong, F. M. Ng, B. Liu, Y. X. Wong, Z. Y. Poh, S. Liu, S. W. Then, M. Y. Lee, H. Q. Ng, Q. Huang, A. W. Hung, J. Cherian, J. Hill, T. H. Keller and C. Kang, Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy. J. Biol. Chem. 291, 17743–17753 (2016)
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