LIU Shuang Lab

Shuang LIU, Ph.D.
Principal Investigator, Institute of Molecular and Cell Biology, A*STAR

Adjunct Assistant Professor, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore

Honorary Principal Investigator, Neurobiology Research Programme, Life Sciences Institute, National University of Singapore

Shuang is a National Science Scholarship (BS-PhD) scholar and obtained her undergraduate degree in Chemistry with Medicinal Chemistry from Imperial College London. She then spent a year at ASTAR’s Experimental Therapeutics Centre, where she identified several exploratory and lead-stage compounds against various therapeutic targets using fragment-based screening. Shuang completed her DPhil in Chemical Biology at the University of Oxford under the guidance of Prof. Christopher Schofield, focusing on mechanistic and inhibition studies of oncogenic variants of isocitrate dehydrogenase 1. She then moved to the Broad Institute of MIT and Harvard/Harvard University for her postdoctoral training in the laboratory of Prof. Stuart Schreiber, where she pioneered the rational discovery of bifunctional and molecular glue-like compounds using DNA-encoded library (DEL) screening. This work was among the first to systematically identify molecular glues (MGs) using a high-throughput platform. Shuang returned to IMCB, ASTAR in 2023 to start her independent research on molecular glue discovery. Her work is supported by the A*STAR Young Achiever Award and the National Research Foundation Fellowship.

Nafizul KAZI

Scientist

PhD in Chemical Biology

Max Planck Institute, Germany

MG for Protein Stability

James ZHANG

Scientist

PhD in Chemical Biology

Imperial College London, UK

MG for Signalling Regulation

Dzung NGUYEN

Scientist

PhD in Structure-based Drug Design

Marburg University, Germany

Previous affiliation: Bayer AG

MG for Protein Complex Modulation

Ee Moon CHIN

PhD student (AGS)

BSc (Hons) in Chemistry

National University of Singapore

MG for RNA Regulation

Alumni

Interns

Oscar Zhao Tianqin (2024, 2025), Yunke Luo (2024, 2025), Wendy Wang Kehan (2025), Lieen Ma (2025), Wencheng Song (2025), Wenqi Ke (2025), Ee Moon Chin (2025)

Local Student Attachment Programme (JC)

Daniel Ho Dawei (2024), Wanqing Ning (2024), Dylan Chin Hao Ching (2025), Lewis Tan Kai Shuen (2025)

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Shuang LIU, Ph.D.Principal Investigator, Institute of Molecular and Cell Biology, A*STAR

Shuang LIU, Ph.D.
Principal Investigator, Institute of Molecular and Cell Biology, A*STAR