Shuang LIU, Ph.D. Principal Investigator, Institute of Molecular and Cell Biology, A*STAR
Shuang is a National Science Scholarship (BS-PhD) scholar and obtained her undergraduate degree in Chemistry with Medicinal Chemistry from Imperial College London. She then spent a year at A*STAR’s Experimental Therapeutics Centre, where she identified several exploratory and lead-stage compounds against various therapeutic targets using fragment-based screening. Shuang completed her DPhil in Chemical Biology at the University of Oxford under the guidance of Prof. Christopher Schofield, focusing on mechanistic and inhibition studies of oncogenic variants of isocitrate dehydrogenase 1. She then moved to the Broad Institute of MIT and Harvard/Harvard University for her postdoctoral training in the laboratory of Prof. Stuart Schreiber, where she pioneered the rational discovery of bifunctional and molecular glue-like compounds using DNA-encoded library (DEL) screening. This work was among the first to systematically identify molecular glues (MGs) using a high-throughput platform. Shuang returned to IMCB, A*STAR in 2023 to start her independent research on molecular glue discovery. Her work is supported by the A*STAR Young Achiever Award and the National Research Foundation Fellowship.