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The current bottleneck in drug discovery is the challenge of targeting 80% of the human proteome once considered undruggable. Molecular glues are small molecules that induce non-native interactions between proteins, enabling the modulation of key cellular processes such as protein degradation, inhibition, activation, and stabilisation. Despite their immense therapeutic potential, molecular glue discovery has largely been serendipitous.
At A*STAR Institute of Molecular and Cell Biology (IMCB), we use DNA-encoded library screening to systematically discover new molecular glues. Our research aims to harness their potential to overcome drug resistance, inhibit previously intractable protein-protein interactions, stabilise proteins, and modulate post-translational modifications. By bridging the gap between biological discoveries and drug development, we advance chemical biology to deepen our understanding of fundamental biological processes, and drive promising hits and leads towards preclinical and clinical candidates.
The Liu lab at A*STAR IMCB, Singapore (www.liuslab.com) is seeking two highly motivated scientists to join our team and contribute to molecular glue discovery using DNA-encoded library (DEL) screening.
The successful candidate(s) will work at the interface of experimental science, data analysis and drug discovery. The role will involve conducting DEL screens, analysing sequencing data, prioritising compounds, and validating selected hits using biochemical, biophysical and cellular assays.
🔎 Key areas:
• DNA-encoded library screening
• Next-generation sequencing data analysis and visualisation
• Cheminformatics and chemical structure analysis
• Recombinant protein expression and purification
• Biochemical, biophysical and cellular validation of selected compounds
Training will be provided in areas where the candidate has less prior experience.
We offer a competitive salary package, with a housing allowance for international applicants.
💼 Requirements:
• PhD in Chemical Biology, Chemistry, Biochemistry, Biophysics, Biology, Bioinformatics or a related field
• Wet-lab experience in biochemical, biophysical or cellular experiments
• A good understanding of chemistry and chemical structures
Experience in one or more of the following areas would be advantageous but is not essential:
• DNA-encoded library screening
• Working knowledge in Python and R to analyse large data sets
• Recombinant protein expression and purification
• Biophysical assays
• Cancer biology
• Induced-proximity therapeutics
• Machine learning or statistical modelling
📧 To apply, please email your CV and a brief description of your relevant wet-lab experience to Dr Shuang Liu at liu_shuang@a-star.edu.sg.
Only shortlisted candidates will be contacted for interviews.
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